| 1957 |
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In the USA, Dr. Frederick L. Crane isolated a quinon as yellow compound from beef heart mitochondria and named it Coenzyme Q, meaning the coenzyme of respiratory chain.
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| 1957 |
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Dr. Morton in the United Kingdom isolated the same substance from vitamin A deficient rat liver. Dr. Morton named it ubiquinone, meaning the ubiquitous quinone which widely exists in a human, animal, and microorganism etc.
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| 1974 |
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CoQ10 was approved as a medicine for congestive heart failure (Ubidecarenone) in Japan.
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| 1990s |
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CoQ10 began to be used as a dietary supplement in the USA, and as a cosmetic in Germany.
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| 2001 |
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Japanese Ministry of Health, Labour and Welfare permitted the use of CoQ10 as food.
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| 2004 |
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Japanese TV programs showed impressively the effect of CoQ10. The consumption of CoQ10 in Japan had increased rapidly. In October, Japanese Ministry of Health, Labour and Welfare permitted the use of CoQ10 as a cosmetic.
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| 2007 |
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The 50th anniversary of the discovery of CoQ10. The 5th conference of the International Coenzyme Q10 Association was held in Kobe in Japan on November 9 to 12.
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